EBOO & Ozone Therapy: A Promising Path for Lyme Support
Introduction
Lingering Lyme symptoms—fatigue, brain fog, pain—can leave patients searching for answers. While antibiotics remain the standard, interest is growing in EBOO (Extracorporeal Blood Oxygenation and Ozonation) and ozone therapy as potential adjuncts. Below, we break down how these therapies work, the evidence behind them, and safety considerations.
What Are EBOO and Ozone Therapy?
Ozone Therapy: The controlled use of ozone (O₃) to trigger immune modulation, improve oxygen delivery, and fight microbes. It’s delivered via routes like major autohemotherapy (MAH). Evidence suggests ozone activates antioxidant pathways and has antimicrobial activity [1].
EBOO: An advanced form of ozone therapy in which several liters of blood are filtered, oxygenated, and ozonated through a dialysis-like circuit, then reinfused. This delivers broader systemic exposure than MAH [2][3].
Mechanisms & Potential Benefits
Immune Modulation – Ozone activates the Nrf2/HO-1 antioxidant pathway, helping regulate inflammation [1].
Detoxification – EBOO simultaneously filters inflammatory proteins while oxygenating blood [4].
Anti-Biofilm & Antimicrobial Effects – Ozone disrupts microbial membranes and may weaken biofilms, which are linked to Lyme persistence [5].
Improved Oxygen Delivery – Ozonated blood improves red blood cell flexibility, enhancing oxygen delivery to tissues [6].
Evidence Snapshot
Clinical Studies (Non-Lyme): EBOO improved outcomes in peripheral arterial disease patients, outperforming prostacyclin for ischemic lesions [7].
Wider Use: More than 1,200 EBOO treatments have been performed across vascular/metabolic conditions with positive safety signals [2].
Ozone in Research: Reviews show ozone therapy supports chronic pain, inflammation, and fatigue but call for more controlled trials [8].
Lyme-Specific Evidence: Data is limited to anecdotal reports and integrative clinic case studies; no randomized trials exist [9].
Safety & Contraindications
Risks: Misadministration can cause gas embolism, lung damage, or cardiovascular issues. Ozone inhalation is toxic [10].
Contraindications: G6PD deficiency, pregnancy, uncontrolled hyperthyroidism, severe anemia, or clotting disorders [11].
FDA Stance: The FDA warns that ozone is not proven safe or effective for any medical condition [10].
Conclusion
EBOO and ozone therapy offer intriguing biological plausibility and patient-reported benefits, but remain investigational for Lyme disease. If pursued, they should only be used alongside standard antibiotic care, under professional supervision, with informed consent.
References
Bocci V. Ozone as a bioregulator: pharmacology and toxicology of ozone therapy today. Med Gas Res. 2017. https://pmc.ncbi.nlm.nih.gov/articles/PMC5674660/
Di Paolo N, et al. Extracorporeal blood oxygenation and ozonation (EBOO): a clinical experience. Int J Artif Organs. 2005. https://pubmed.ncbi.nlm.nih.gov/16156950/
The Blend Institute. EBOO and MAH: Two powerful paths to oxygenate, detoxify, and rejuvenate. 2023. https://www.theblendinstitute.com/blog/eboo-and-mah-two-powerful-paths-to-oxygenate-detoxify-and-rejuvenate
Extension Health. EBOO Ozone Therapy. 2024. https://extension.health/eboo-ozone-therapy/
Meeting Point Health. Ozone therapy for Lyme disease. 2023. https://www.meetingpointhealth.com/ozone-therapy-for-lyme-disease/
Asandra MD. EBOO Ozone Therapy – Beverly Hills. 2023. https://asandramd.com/anti-aging-beverly-hills/eboo-ozone-therapy/
Di Paolo N, et al. Extracorporeal blood oxygenation and ozonation versus prostacyclin in peripheral arterial disease. Int J Artif Organs. 2005. https://journals.sagepub.com/doi/10.1177/039139880502801012
Hidalgo-Tallón FJ, et al. Ozone therapy in pain medicine: Updated review. Front Physiol. 2022. https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-024-01976-4
Project Lyme. Ozone Therapy for Lyme Disease. 2022. https://projectlyme.org/ozone-therapy-for-lyme-disease/
FDA & Health.com. Ozone therapy warnings. 2023. https://www.health.com/ozone-therapy-8660621
IV Elements. EBOO Ozone Therapy: Contraindications & Safety. 2023. https://ivelements.net/blog/eboo-ozone
